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EnglishCatalog No : | IPB4194 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-2000 ELISA: 1:10000-20000 |
Gene Name: | LASP1 MLN50 |
Protein Name: | LIM and SH3 domain protein 1 |
Human Gene Id: | 3927 |
Swiss-Prot: | Q14847 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm, cell cortex Cytoplasm, cytoskeleton Associated with the F-actin rich cortical cytoskeleton |
MW: | - |
Background: | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain LIMK1 is a serine:threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure This protein also stimulates axon growth and may play a role in brain development LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog |
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