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EnglishCatalog No : | IPB4185 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:5000 |
Gene Name: | ARHGEF2 |
Protein Name: | Rho guanine nucleotide exchange factor 2 |
Human Gene Id: | 9181 |
Swiss-Prot: | Q92974 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm, cytoskeleton Cytoplasm Cell junction, tight junction Golgi apparatus Cytoplasm, cytoskeleton, spindle Cell projection, ruffle membrane Cytoplasmic vesicle Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085) Recruited into membrane ruffles induced by Sflexneri at tight junctions of polarized epithelial cells (PubMed:19043560) Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730) |
MW: | 111543 |
Background: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors The encoded protein may form complex with G proteins and stimulate rho-dependent signals Alternatively spliced transcript variants encoding different isoforms have been identified |
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