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EnglishCatalog No : | IPB3902 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | CSF2RB |
Protein Name: | Cytokine receptor common subunit beta |
Human Gene Id: | 1439 |
Swiss-Prot: | P32927 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Membrane; Single-pass type I membrane protein |
MW: | 97336 |
Background: | The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells This cytokine is a ligand for interleukin 4 receptor The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13 STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13 This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported |
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