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EnglishCatalog No : | IPB0339 |
Reactivity: | Human; Mouse; |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:10000 |
Gene Name: | DAPP1 |
Protein Name: | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide |
Human Gene Id: | 27071 |
Swiss-Prot: | Q9UN19 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Membrane; Peripheral membrane protein Membrane-associated after cell stimulation leading to its translocation |
MW: | 32194 |
Background: | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K,induction: Upon B-cell activation,PTM: Phosphorylated on tyrosine residues,similarity: Contains 1 PH domain,similarity: Contains 1 SH2 domain,subcellular location: Membrane-associated after cell stimulation leading to its translocation,subunit: Interacts with PtdIns(3,4,5)P3 and PLCG2 In vitro, interacts with PtdIns(3,4)P2,tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells |
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