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N:H:K-Ras Polyclonal Antibody

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¥1900.00元/format:100ul

目录号:IPB0293

库存:现货
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Catalog No :IPB0293
Reactivity:Human; Mouse; Rat
Applications:WB; IHC-p; IF/ICC; ELISA
Dilution:WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200
Gene Name:NRAS:HRAS:KRAS
Protein Name:GTPase Nras/GTPase Hras/GTPase Kras
Human Gene Id:3265:3845:4893
Swiss-Prot:P01111:P01112:P01116
Formulation:Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide
Source:Rabbit
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Concentration:1 mg/ml
Storage&Stability:-20°C/1 year
Subcellular Location:Cell membrane; Lipid-anchor; Cytoplasmic side Golgi apparatus membrane; Lipid-anchor Shuttles between the plasma membrane and the Golgi apparatus
MW:21298/21656
Background:This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia

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