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EnglishCatalog No : | IPB0201 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:10000 |
Gene Name: | BCL2L2 |
Protein Name: | Bcl-2-like protein 2 |
Human Gene Id: | 599 |
Swiss-Prot: | Q92843 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Mitochondrion membrane; Peripheral membrane protein Loosely associated with the mitochondrial membrane in healthy cells During apoptosis, tightly bound to the membrane |
MW: | 20774 |
Background: | This gene encodes a member of the BCL-2 protein family The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis Alternative splicing results in multiple transcript variants Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene |
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