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EnglishCatalog No : | IPB0196 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:10000 |
Gene Name: | SERPINA1 |
Protein Name: | Alpha-1-antitrypsin |
Human Gene Id: | 5265 |
Swiss-Prot: | P01009 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Secreted Endoplasmic reticulum The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix |
MW: | 46737 |
Background: | The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator Defects in this gene can cause emphysema or liver disease Several transcript variants encoding the same protein have been found for this gene |
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