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| Catalog No ： | IPB0181 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
| Gene Name： | FOXO3 |
| Protein Name： | Forkhead box protein O3 |
| Human Gene Id： | 2309 |
| Swiss-Prot： | O43524 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm, cytosol Nucleus Mitochondrion matrix Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106) Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106) Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity) Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193) Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity) |
| MW： | 71277 |
| Background： | This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death Translocation of this gene with the MLL gene is associated with secondary acute leukemia Alternatively spliced transcript variants encoding the same protein have been observed |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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