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EnglishCatalog No : | IPB0155 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 |
Gene Name: | NR1H3 |
Protein Name: | Oxysterols receptor LXR-alpha |
Human Gene Id: | 10062 |
Swiss-Prot: | Q13133 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus Cytoplasm |
MW: | 50396 |
Background: | The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation This protein is highly expressed in visceral organs, including liver, kidney and intestine It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis Alternatively spliced transcript variants encoding different isoforms have been found for this gene |
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