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| Catalog No ： | IPB0125 |
| Reactivity： | Human; Mouse; |
| Applications： | IF/ICC; WB; IHC-p; ELISA |
| Dilution： | IF: 1:50-200 WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | TLR4 |
| Protein Name： | Toll-like receptor 4 |
| Human Gene Id： | 7099 |
| Swiss-Prot： | O00206 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell membrane; Single-pass type I membrane protein Early endosome Cell projection, ruffle Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584) Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation |
| MW： | 95680 |
| Background： | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity TLRs are highly conserved from Drosophila to humans and share structural and functional similarities They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity The various TLRs exhibit different patterns of expression This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria Mutations in this gene have been associated with differences in LPS responsiveness Multiple transcript variants encoding different isoforms have been found for this gene |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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