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EnglishCatalog No : | IPB0123 |
Reactivity: | Human; Mouse; Rat |
Applications: | IF/ICC; WB; IHC-p; ELISA |
Dilution: | IF: 1:50-200 WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 |
Gene Name: | CD63 |
Protein Name: | CD63 antigen |
Human Gene Id: | 967 |
Swiss-Prot: | P08962 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Multi-pass membrane protein Lysosome membrane; Multi-pass membrane protein Late endosome membrane; Multi-pass membrane protein Endosome, multivesicular body Melanosome Secreted, extracellular exosome Cell surface Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155) Located in platelet dense granules (PubMed:7682577) Detected in a subset of pre-melanosomes Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903) |
MW: | 25637 |
Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility The encoded protein is a cell surface glycoprotein that is known to complex with integrins It may function as a blood platelet activation marker Deficiency of this protein is associated with Hermansky-Pudlak syndrome Also this gene has been associated with tumor progression Alternative splicing results in multiple transcript variants encoding different protein isoforms |
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