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| Catalog No ： | IPB0066 |
| Reactivity： | Human; Mouse; Rat; Monkey |
| Applications： | WB; IHC-p; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:20000 |
| Gene Name： | PCNA |
| Protein Name： | Proliferating cell nuclear antigen |
| Human Gene Id： | 5111 |
| Swiss-Prot： | P12004 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Nucleus Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902) Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136) Co-localizes with SMARCA5:SNF2H and BAZ1B:WSTF at replication foci during S phase (PubMed:15543136) Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents |
| MW： | 28769 |
| Background： | The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway Two transcript variants encoding the same protein have been found for this gene Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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