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EnglishCatalog No : | IPB0064 |
Reactivity: | Human; Mouse; Rat |
Applications: | IHC-p; IF/ICC; ELISA |
Dilution: | IHC: 1:100-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
Gene Name: | MKI67 |
Protein Name: | Antigen KI-67 |
Human Gene Id: | 4288 |
Swiss-Prot: | P46013 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Chromosome Nucleus Nucleus, nucleolus Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226) Associates with satellite DNA in G1 phase (PubMed:9510506) Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106) Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106) |
MW: | 360KD |
Background: | This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation Alternatively spliced transcript variants have been described A related pseudogene exists on chromosome X |
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