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EnglishCatalog No : | IPB0049 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-2000 IHC: 1:50-1:200 ELISA: 1:10000-20000 |
Gene Name: | TGFB2 |
Protein Name: | Transforming growth factor beta-2 (TGF-beta-2) (BSC-1 cell growth inhibitor) (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) (Polyergin) |
Human Gene Id: | 7042 |
Swiss-Prot: | P61812 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix [Transforming growth factor beta-2]: Secreted |
MW: | - |
Background: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer The mature peptide may also form heterodimers with other TGF-beta family members Disruption of the TGF-beta:SMAD pathway has been implicated in a variety of human cancers A chromosomal translocation that includes this gene is associated with Peters&apos |
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