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EnglishCatalog No : | IPB0021 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | CD3E |
Protein Name: | T-cell surface glycoprotein CD3 epsilon chain |
Human Gene Id: | 916 |
Swiss-Prot: | P07766 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Single-pass type I membrane protein |
MW: | 23147 |
Background: | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha:beta and gamma:delta heterodimers, forms the T-cell receptor-CD3 complex This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11 The epsilon polypeptide plays an essential role in T-cell development Defects in this gene cause immunodeficiency This gene has also been linked to a susceptibility to type I diabetes in women |
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