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EnglishCatalog No. : | IMB0102 |
Reactivity: | Human;Mouse;Rat;Monkey |
Applications: | WB; IHC-p; IF/ICC; FCM; ELISA |
Gene Name: | GSK3B |
Protein Name: | Glycogen synthase kinase-3 beta |
Human Gene Id: | 2942 |
Swiss-Prot: | P49841 |
Formulation: | Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol. |
Source: | Monoclonal, Mouse |
Dilution: | WB: 1:500-1:2000 IHC: 1:200-1:1000 IF: 1:200-1:1000 FCM: 1:200-1:400 ELISA: 1:10000 |
PurIF:ication: | Affinity purIF:ication |
Concentration: | nan |
Storage&Stability: | -20°C/1 year |
Background: | The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modIF:ying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding dIF:ferent isoforms have been found for this gene.[provided by RefSeq, Sep 2009], |
Subcellular Location.: | Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). . |
BiowMW: | nan |
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