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EnglishCatalog No. : | IML0828 |
Reactivity: | Human |
Applications: | IHC-p; IF(paraffin section) |
Gene Name: | GPC3 OCI5 |
Protein Name: | Glypican-3(GPC3) |
Human Gene Id: | 2719 |
Swiss-Prot: | P51654 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.143% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | IHC-p: 1:100-200 IF: 1:100-500 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | 0.7mg:mL |
Storage&Stability: | -20°C:1 year |
Background: | Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009], |
Subcellular Location: | proteinaceous extracellular matrix,extracellular space,Golgi lumen,plasma membrane,integral component of plasma membrane,anchored component of membrane,lysosomal lumen,anchored component of plasma membrane,extracellular exosome, |
BiowMW: | nan |
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