中文
EnglishCatalog No. : | IML0822 |
Reactivity: | Human |
Applications: | IHC-p; IF(paraffin section) |
Gene Name: | MYH11 KIAA0866 |
Protein Name: | Myosin Heavy Chain, Smooth Muscle |
Human Gene Id: | 4629 |
Swiss-Prot: | P35749 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.134% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | IHC-p: 1:100-200 IF: 1:100-500 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | 0.93mg:mL |
Storage&Stability: | -20°C:1 year |
Background: | The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alter |
Subcellular Location: | Colon, Smooth muscle, Breast |
BiowMW: | nan |
SPECIES
APPLICATION
TITLE