中文
EnglishCatalog No. : | IML0066 |
Reactivity: | Human; Mouse |
Applications: | IHC-p |
Gene Name: | AMACR |
Protein Name: | AMACR |
Human Gene Id: | 23600 |
Swiss-Prot: | Q9UHK6 |
Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Source: | Monoclonal, Mouse:IgG1, Kappa |
Dilution: | IHC-p: 1:100-200 |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | 0.52mg:mL |
Storage&Stability: | -20°C:1 year |
Background: | This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. |
Subcellular Location: | Cytoplasmic |
BiowMW: | nan |
SPECIES
APPLICATION
TITLE