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EnglishCatalog No : | IPB14458 |
Reactivity: | Human; Mouse; |
Applications: | ELISA |
Dilution: | ELISA 1:10000-20000 |
Gene Name: | APOB |
Protein Name: | Apolipoprotein B-100 |
Human Gene Id: | 338 |
Swiss-Prot: | P04114 |
Formulation: | Liquid in PBS |
Source: | Nano-antibody with his-tag, Camel |
Purification: | The antibody was affinity-purified nickel column using his-tag in antibody |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Secreted Lipid droplet |
MW: | - |
Background: | This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA The two isoforms share a common N-terminal sequence The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels |
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