中文
EnglishCatalog No : | IPB14432 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB |
Dilution: | WB: 1:500-2000 |
Gene Name: | GRIN2A NMDAR2A |
Protein Name: | NMDARA2 |
Human Gene Id: | 2903 |
Swiss-Prot: | Q12879 |
Formulation: | Liquid in PBS containing 50% glycerol, and 071% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell projection, dendritic spine Cell membrane; Multi-pass membrane protein Cell junction, synapse Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex |
MW: | 161040 |
Background: | This gene encodes a member of the glutamate-gated ion channel protein family The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation Alternative splicing results in multiple transcript variants |
SPECIES
APPLICATION
TITLE