中文
EnglishCatalog No : | IPB14395 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB |
Dilution: | WB: 1:500-2000 |
Gene Name: | XRCC1 |
Protein Name: | XRCC1 |
Human Gene Id: | 7515 |
Swiss-Prot: | P18887 |
Formulation: | Liquid in PBS containing 50% glycerol, and 034% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus Moves from the nucleoli to the global nuclear chromatin upon DNA damage |
MW: | 69630 |
Background: | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway It may play a role in DNA processing during meiogenesis and recombination in germ cells A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity |
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