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| Catalog No ： | IPB14371 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB |
| Dilution： | WB: 1:500-2000 |
| Gene Name： | SPHK1 SPHK SPK |
| Protein Name： | SPHK1 |
| Human Gene Id： | 8877 |
| Swiss-Prot： | Q9NYA1 |
| Formulation： | Liquid in PBS containing 50% glycerol, and 008% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Nucleus Cell membrane Endosome membrane; Peripheral membrane protein Membrane, clathrin-coated pit Cell junction, synapse Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831) Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359) Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity) |
| MW： | 42240 |
| Background： | sphingosine kinase 1(SPHK1) Homo sapiens The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes Alternatively spliced transcript variants encoding different isoforms have been found for this gene [provided by RefSeq, Sep 2011], |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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