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EnglishCatalog No : | IPB14042 |
Reactivity: | Human; Mouse; |
Applications: | WB |
Dilution: | WB: 1:500-2000 |
Gene Name: | WBSCR22 HUSSY-03 PP3381 |
Protein Name: | WBS22 |
Human Gene Id: | 114049 |
Swiss-Prot: | O43709 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus Nucleus, nucleoplasm Cytoplasm, perinuclear region Cytoplasm Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492) Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604) Localization is not affected by glucocorticoid treatment (PubMed:24488492) |
MW: | 30910 |
Background: | This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q1123 Alternatively spliced transcript variants have been found |
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