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EnglishCatalog No : | IPB12561 |
Reactivity: | Human; Mouse; |
Applications: | WB |
Dilution: | WB: 1:500-2000 |
Gene Name: | DSE SART2 |
Protein Name: | DSE |
Human Gene Id: | 29940 |
Swiss-Prot: | Q9UL01 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 0249% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Endoplasmic reticulum membrane; Multi-pass membrane protein Golgi apparatus membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein |
MW: | - |
Background: | The protein encoded by this gene is a tumor-rejection antigen It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome Alternative splicing results in multiple transcript variants A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18 |
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