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EnglishCatalog No : | IPB4221 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:5000 |
Gene Name: | LRG1 |
Protein Name: | Leucine-rich alpha-2-glycoprotein |
Human Gene Id: | 116844 |
Swiss-Prot: | P02750 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Secreted |
MW: | 38178 |
Background: | This gene encodes a member of the low-density lipoprotein receptor family of proteins The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712) This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients |
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