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| Catalog No ： | IPB4196 |
| Reactivity： | Human; Mouse; Rat; Monkey |
| Applications： | WB; IHC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | LIMK1:LIMK2 |
| Protein Name： | LIM domain kinase 1/LIM domain kinase 2 |
| Human Gene Id： | 3984:3985 |
| Swiss-Prot： | P53667:P53671 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Nucleus Cytoplasm, cytoskeleton Cell projection, lamellipodium Predominantly found in the cytoplasm Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B:LRAP25-dependent manner |
| MW： | 72601 |
| Background： | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton At least three transcript variants encoding different isoforms have been found for this gene |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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