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EnglishCatalog No : | IPB4191 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 |
Gene Name: | LIF |
Protein Name: | Leukemia inhibitory factor |
Human Gene Id: | 3976 |
Swiss-Prot: | P15018 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Secreted |
MW: | 22220 |
Background: | This gene encodes a protein that belongs to the type I cytokine receptor family This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland Multiple splice variants encoding the same protein have been found for this gene |
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