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| Catalog No ： | IPB4153 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IHC; ELISA |
| Dilution： | IHC: 1:50-1:200 ELISA: 1:10000 |
| Gene Name： | KCND2 |
| Protein Name： | Potassium voltage-gated channel subfamily D member 2 |
| Human Gene Id： | 3751 |
| Swiss-Prot： | Q9NZV8 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell membrane; Multi-pass membrane protein Cell projection, dendrite Cell junction, synapse Perikaryon Cell junction, synapse, postsynaptic cell membrane Cell projection, dendritic spine Cell junction In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer Detected at GABAergic synapses Detected at cell junctions that are distinct from synaptic cell contacts Detected in lipid rafts Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (PubMed:15454437) Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed:15454437, PubMed:24811166) Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity) Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552 Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity) |
| MW： | 70577 |
| Background： | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume This gene encodes a member of the potassium voltage-gated channel subfamily V This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits This protein is strongly expressed in pancreas and has a weaker expression in several other tissues |
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