中文
EnglishCatalog No : | IPB4150 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:10000 |
Gene Name: | KCNC2 |
Protein Name: | Potassium voltage-gated channel subfamily C member 2 |
Human Gene Id: | 3747 |
Swiss-Prot: | Q96PR1 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Multi-pass membrane protein Membrane; Multi-pass membrane protein Perikaryon Cell projection, axon Cell projection, dendrite Cell junction, synapse, postsynaptic cell membrane Cell junction, synapse, presynaptic cell membrane Cell junction, synapse, synaptosome Cell junction, synapse Apical cell membrane Basolateral cell membrane Colocalizes with parvalbumin in globus pallidus neurons Localizes in thalamocortical axons and synapses Localizes on the surface of cell somata, proximal dendrites and axonal membranes Also detected throughout the neuropil Localized in starburst cell somata and proximal dendrite processes Colocalized with GABA in presynaptic terminals Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites |
MW: | 70226 |
Background: | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies Based on sequence similarity, this gene is similar to the Shaw subfamily The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes It generates atypical voltage-dependent transient current that may be important for neuronal excitability Multiple transcript variants have been found for this gene |
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