中文
EnglishCatalog No : | IPB3895 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IF: 1:50-1:200 ELISA: 1:10000 |
Gene Name: | IL2RB |
Protein Name: | Interleukin-2 receptor subunit beta |
Human Gene Id: | 3560 |
Swiss-Prot: | P14784 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Single-pass type I membrane protein |
MW: | 61117 |
Background: | The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2 The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction The intermediate affinity form consists of an alpha:beta subunit heterodimer, while the high affinity form consists of an alpha:beta:gamma subunit heterotrimer Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2 The protein encoded by this gene represents the beta subunit and is a type I membrane protein The use of alternative promoters results in multiple transcript variants encoding the same protein The protein is primarily expressed in the hematopoietic system |
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