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IL-12B Polyclonal Antibody

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¥1900.00元/format:100ul

目录号:IPB3852

库存:现货
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Catalog No :IPB3852
Reactivity:Human; Mouse; Rat
Applications:WB; ELISA
Dilution:WB: 1:500-1:2000 ELISA: 1:5000
Gene Name:IL12B
Protein Name:Interleukin-12 subunit beta
Human Gene Id:3593
Swiss-Prot:P29460
Formulation:Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide
Source:Rabbit
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Concentration:1 mg/ml
Storage&Stability:-20°C/1 year
Subcellular Location:Secreted
MW:37169
Background:The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections Alternative splicing results in multiple transcript variants

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