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EnglishCatalog No : | IPB3852 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:5000 |
Gene Name: | IL12B |
Protein Name: | Interleukin-12 subunit beta |
Human Gene Id: | 3593 |
Swiss-Prot: | P29460 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Secreted |
MW: | 37169 |
Background: | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections Alternative splicing results in multiple transcript variants |
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