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| Catalog No ： | IPB0360 |
| Reactivity： | Human; Mouse; Rat; Monkey |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
| Gene Name： | CTNNB1 |
| Protein Name： | Catenin beta-1 |
| Human Gene Id： | 1499 |
| Swiss-Prot： | P35222 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm Nucleus Cytoplasm, cytoskeleton Cell junction, adherens junction Cell junction Cell membrane Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cell junction, synapse Cytoplasm, cytoskeleton, cilium basal body Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity) Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1 Translocates to the nucleus when it is stabilized (low level of phosphorylation) Interaction with GLIS2 and MUC1 promotes nuclear translocation Interaction with EMD inhibits nuclear localization The majority of beta-catenin is localized to the cell membrane In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250 In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871) |
| MW： | 85497 |
| Background： | The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer Alternative splicing results in multiple transcript variants |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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