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| Catalog No ： | IPB0357 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | CASP4 |
| Protein Name： | Caspase4 |
| Human Gene Id： | 837 |
| Swiss-Prot： | P49662 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm, cytosol Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Mitochondrion Inflammasome Secreted Predominantly localizes to the endoplasmic reticulum (ER) Association with the ER membrane requires TMEM214 (PubMed:15123740) Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630) |
| MW： | 43262 |
| Background： | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor When overexpressed, this gene induces cell apoptosis Alternative splicing results in transcript variants encoding distinct isoforms |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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