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| Catalog No ： | IPB0351 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
| Gene Name： | ABL1 |
| Protein Name： | Tyrosine-protein kinase ABL1 |
| Human Gene Id： | 25 |
| Swiss-Prot： | P00519 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cytoplasm, cytoskeleton Nucleus Mitochondrion Shuttles between the nucleus and cytoplasm depending on environmental signals Sequestered into the cytoplasm through interaction with 14-3-3 proteins Localizes to mitochondria in response to oxidative stress (By similarity) [Isoform IB]: Nucleus membrane; Lipid-anchor The myristoylated c-ABL protein is reported to be nuclear |
| MW： | 122873 |
| Background： | This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410) Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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