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EnglishCatalog No : | IPB0349 |
Reactivity: | Human; Mouse; Rat; Monkey |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | CEBPA |
Protein Name: | CCAAT/enhancer-binding protein alpha |
Human Gene Id: | 1050 |
Swiss-Prot: | P49715 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Nucleus [Isoform 4]: Nucleus, nucleolus |
MW: | 37575 |
Background: | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes The encoded protein functions in homodimers and also heterodimers with CCAAT:enhancer-binding proteins beta and gamma Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis Mutation of this gene is associated with acute myeloid leukemia The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons |
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