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| Catalog No ： | IPB0348 |
| Reactivity： | Human; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:5000 |
| Gene Name： | BRCA1 |
| Protein Name： | Breast cancer type 1 susceptibility protein |
| Human Gene Id： | 672 |
| Swiss-Prot： | P38398 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Nucleus Chromosome Cytoplasm Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126) Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719) [Isoform 3]: Cytoplasm [Isoform 5]: Cytoplasm |
| MW： | 207721 |
| Background： | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene Many alternatively spliced transcript varian |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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