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| Catalog No ： | IPB0337 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | ATR |
| Protein Name： | Serine/threonine-protein kinase ATR |
| Human Gene Id： | 545 |
| Swiss-Prot： | Q13535 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Nucleus Chromosome Depending on the cell type, it can also be found in PML nuclear bodies Recruited to chromatin during S-phase Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling |
| MW： | 301367 |
| Background： | The protein encoded by this gene belongs the PI3:PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1 Mutations of this gene are associated with Seckel syndrome An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known Transcript variants utilizing alternative polyA sites exist |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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