中文
EnglishCatalog No : | IPB0335 |
Reactivity: | Human; Mouse; |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:20000 |
Gene Name: | ATG4B |
Protein Name: | Cysteine protease ATG4B |
Human Gene Id: | 23192 |
Swiss-Prot: | Q9Y4P1 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm Cytoplasm, cytosol Cytoplasmic vesicle, autophagosome Endoplasmic reticulum Mitochondrion Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041) A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041) |
MW: | 44309 |
Background: | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed This gene encodes a member of the autophagin protein family The encoded protein is also designated as a member of the C-54 family of cysteine proteases Alternate transcriptional splice variants, encoding different isoforms, have been characterized |
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