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EnglishCatalog No : | IPB0330 |
Reactivity: | Human; Mouse; Rat; Monkey |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:10000 |
Gene Name: | AQP2 |
Protein Name: | Aquaporin-2 |
Human Gene Id: | 359 |
Swiss-Prot: | P41181 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Apical cell membrane; Multi-pass membrane protein Basolateral cell membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein Shuttles from vesicles to the apical membrane (PubMed:15509592) Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592) PLEKHA8:FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity) |
MW: | 28837 |
Background: | This gene encodes a water channel protein located in the kidney collecting tubule It belongs to the MIP:aquaporin family, some members of which are clustered together on chromosome 12q13 Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus |
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