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EnglishCatalog No : | IPB0314 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 ELISA: 1:5000 IF: 1:50-1:200 |
Gene Name: | ABCG5 |
Protein Name: | ATP-binding cassette sub-family G member 5 (Sterolin-1) |
Human Gene Id: | 64240 |
Swiss-Prot: | Q9H222 |
Formulation: | Liquid in PBS containing 50% glycerol, and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Multi-pass membrane protein Apical cell membrane; Multi-pass membrane protein |
MW: | - |
Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1, MDR:TAP, MRP, ALD, OABP, GCN20, White) This protein is a member of the White subfamily The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols It is expressed in a tissue-specific manner in the liver, colon, and intestine This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8 Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia |
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