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| Catalog No ： | IPB0312 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | IHC-p; ELISA |
| Dilution： | IHC: 1:50-1:200 ELISA: 1:5000 |
| Gene Name： | TP53BP1 |
| Protein Name： | Tumor suppressor p53-binding protein 1 |
| Human Gene Id： | 7158 |
| Swiss-Prot： | Q12888 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Nucleus Chromosome Chromosome, centromere, kinetochore Localizes to the nucleus in absence of DNA damage (PubMed:28241136) Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600) Associated with kinetochores during mitosis (By similarity) |
| MW： | 213574 |
| Background： | May have a role in checkpoint signaling during mitosis (By similarity) Enhances TP53-mediated transcriptional activation Plays a role in the response to DNA damage,PTM: Asymmetrically dimethylated on Arg residues by PRMT1 Methylation is required for DNA binding,PTM: Phosphorylated at basal level in the absence of DNA damage Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation,similarity: Contains 2 BRCT domains,subcellular location: Associated with kinetochores Both nuclear and cytoplasmic in some cells Recruited to sites of DNA damage, such as double stand breaks Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks,subunit: Interacts with IFI202A (By similarity) Binds to the central domain of TP53:p53 May form homo-oligomers Interacts with DCLRE1C Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139' Interacts with histone H4 that has been dimethylated at 'Lys-20' Has low affinity for histone H4 containing monomethylated 'Lys-20' Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20' Has low affinity for histone H3 that has been dimethylated on 'Lys-79' Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro) Does not bind unmethylated histone H3 |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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