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EnglishCatalog No : | IPB0311 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:20000 |
Gene Name: | EIF4EBP1 |
Protein Name: | Eukaryotic translation initiation factor 4E-binding protein 1 |
Human Gene Id: | 1978 |
Swiss-Prot: | Q13541 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | nucleoplasm,cytoplasm,cytosol,protein complex, |
MW: | 12449 |
Background: | This gene encodes one member of a family of translation repressor proteins The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs Interaction of this protein with eIF4E inhibits complex assembly and represses translation This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation |
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