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EnglishCatalog No : | IPB0309 |
Reactivity: | Human; Mouse; Rat |
Applications: | WB; IHC-p; IF/ICC; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | YWHAQ |
Protein Name: | 14-3-3 protein theta |
Human Gene Id: | 10971 |
Swiss-Prot: | P27348 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cytoplasm In neurons, axonally transported to the nerve terminals |
MW: | 27764 |
Background: | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs This gene is upregulated in patients with amyotrophic lateral sclerosis It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease |
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