中文
English
| Catalog No ： | IPB0306 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; ELISA |
| Dilution： | WB: 1:500-2000 ELISA: 1:5000-20000 |
| Gene Name： | SREBF2 BHLHD2 SREBP2 |
| Protein Name： | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into/ Processed sterol regulatory element-binding protein 2] |
| Human Gene Id： | 6721 |
| Swiss-Prot： | Q12772 |
| Formulation： | Liquid in PBS containing 50% glycerol, and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein Golgi apparatus membrane; Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062) Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062) [Processed sterol regulatory element-binding protein 2]: Nucleus Transported into the nucleus with the help of importin-beta Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import |
| MW： | - |
| Background： | This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif Alternate splicing results in multiple transcript variants |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
join our baijia list to stay up to date and get notices about our new releases!
