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| Catalog No ： | IPB0302 |
| Reactivity： | Human; Mouse; |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:20000 |
| Gene Name： | KDR |
| Protein Name： | Vascular endothelial growth factor receptor 2 |
| Human Gene Id： | 3791 |
| Swiss-Prot： | P35968 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell junction Endoplasmic reticulum Cell membrane Localized with RAP1A at cell-cell junctions (By similarity) Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610) [Isoform 1]: Cell membrane; Single-pass type I membrane protein Cytoplasm Nucleus Cytoplasmic vesicle Early endosome Detected on caveolae-enriched lipid rafts at the cell surface Is recycled from the plasma membrane to endosomes and back again Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation VEGFA binding triggers internalization and translocation to the nucleus [Isoform 2]: Secreted [Isoform 3]: Secreted |
| MW： | 151527 |
| Background： | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells This gene encodes one of the two receptors of the VEGF This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc Mutations of this gene are implicated in infantile capillary hemangiomas |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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