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EnglishCatalog No : | IPB0299 |
Reactivity: | Human; Mouse; |
Applications: | WB; IHC-p; ELISA |
Dilution: | WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:40000 |
Gene Name: | CDH5 |
Protein Name: | Cadherin-5 |
Human Gene Id: | 1003 |
Swiss-Prot: | P33151 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell junction Cell membrane; Single-pass type I membrane protein Found at cell-cell boundaries and probably at cell-matrix boundaries KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions |
MW: | 87516 |
Background: | This gene encodes a classical cadherin of the cadherin superfamily The encoded preproprotein is proteolytically processed to generate the mature glycoprotein This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer |
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