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EnglishCatalog No : | IPB0296 |
Reactivity: | Human; Mouse; Rat |
Applications: | IF/ICC; WB; IHC-p; ELISA |
Dilution: | IF: 1:50-200 WB: 1:500-1:2000 IHC: 1:50-1:200 ELISA: 1:5000 |
Gene Name: | RHOA |
Protein Name: | Transforming protein RhoA |
Human Gene Id: | 387 |
Swiss-Prot: | P61586 |
Formulation: | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
Source: | Rabbit |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Concentration: | 1 mg/ml |
Storage&Stability: | -20°C/1 year |
Subcellular Location: | Cell membrane; Lipid-anchor; Cytoplasmic side Cytoplasm, cytoskeleton Cleavage furrow Cytoplasm, cell cortex Midbody Cell projection, lamellipodium Cell projection, dendrite Nucleus Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity) Translocates to the equatorial region before furrow formation in a ECT2-dependent manner Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner |
MW: | 21768 |
Background: | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility Overexpression of this gene is associated with tumor cell proliferation and metastasis Multiple alternatively spliced variants have been identified |
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