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| Catalog No ： | IPB0295 |
| Reactivity： | Human; Mouse; Rat |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC-p: 1:100-1:200 ELISA: 1:20000 IF: 1:50-1:200 |
| Gene Name： | TNFSF11 |
| Protein Name： | Tumor necrosis factor ligand superfamily member 11 |
| Human Gene Id： | 8600 |
| Swiss-Prot： | O14788 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | [Isoform 1]: Cell membrane; Single-pass type II membrane protein [Isoform 3]: Cell membrane; Single-pass type II membrane protein [Isoform 2]: Cytoplasm [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted |
| MW： | 35478 |
| Background： | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss This protein was shown to activate antiapoptotic kinase AKT:PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts The deficient mice exhibited defects in early differentiation of T and B |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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