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| Catalog No ： | IPB0289 |
| Reactivity： | Human; Mouse; |
| Applications： | WB; IHC-p; IF/ICC; ELISA |
| Dilution： | WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200 ELISA: 1:40000 |
| Gene Name： | FASLG |
| Protein Name： | Tumor necrosis factor ligand superfamily member 6 |
| Human Gene Id： | 356 |
| Swiss-Prot： | P48023 |
| Formulation： | Liquid in PBS containing 50% glycerol, 05% BSA and 002% sodium azide |
| Source： | Rabbit |
| Purification： | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Concentration： | 1 mg/ml |
| Storage&Stability： | -20°C/1 year |
| Subcellular Location： | Cell membrane; Single-pass type II membrane protein Cytoplasmic vesicle lumen Lysosome lumen Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290) Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115) [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted May be released into the extracellular fluid by cleavage from the cell surface [FasL intracellular domain]: Nucleus The FasL ICD cytoplasmic form is translocated into the nucleus |
| MW： | 31485 |
| Background： | This gene is a member of the tumor necrosis factor superfamily The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS The FAS:FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death It has also been implicated in the progression of several cancers Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE) Alternatively spliced transcript variants have been described |
SPECIES
APPLICATION
TITLE
Taizhou Baijia Biotechnology Co., Ltd. is a research and development company Production A biotechnology company whose main business is the sale of antibodies / recombinant proteins and related products. Have strict antibody production Quality inspection and quality control system, products cover the whole field of life science.
A103, Beide vaccine center, Binhe Road, west of Lujia Road
Taizhou pharmaceutical high tech Industrial Development Zone
Taizhou, Jiangsu, P.R.C
+8615216892345
bio100plus@126.com
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